The lungs (66%), the bones (28%), and the brain (9%) are the most common sites of spread. Notre satisfaction, cest la vtre! 1969, 98: 384-387. The initial US revealed multiple irregular hypoechoic masses with lobulated irregular margin (red arrow) in the right breast. statement and Explorer le Vietnam dans toute sa grandeur ou juste se relaxer en dcompressant sur des plages paradisiaques. Am J Surg Pathol. Periductal stromal sarcoma may evolve into a phyllodes tumor with time, as well as a specific soft-tissue sarcoma. WebThe tumor microenvironment regulates tissue development and homeostasis, and its dysregulation contributes to neoplastic progression. The histological examination after lumpectomy revealed a periductal stromal sarcoma with free surgical margins. We report the clinical case of a 14-year-old Arabic boy with no history of disease who was presented to our hospital one year ago with a nodule of the right breast that was gradually increasing in size. PSS occurs in pre and post menopausal women with a median of age of 55.3 years [2], and before the present case report it had never been described in a child. Breast periductal stromal tumor (PDST) is a rare biphasic tumor, with both benign ductal epithelium and non-phyllodes sarcomatous stroma. The epithelial component corresponded to ducts with borders, sometimes double and sometimes with mild to moderate hyperplasia without atypia. However, tissue pathology is required for a definitive diagnosis. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. The resection margins were negative (range, 2mm to 13mm). Its therapeutic management is based on wide surgery with free margins. Google Scholar. 2021 Nov 25;10668969211060482. doi: 10.1177/10668969211060482. WebPeriductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Unlike phyllodes tumors, PDST does not present a leaflike architecture. The largest lesion was located 2cm from the areola area, which measured 7.1cm 9.1cm 5.6cm, and internal mass echogenicity was heterogeneous with abundant internal vascularity. Dpartpour Yen Bai via lancien village Duong Lam, balade pied dans ce charmant village, Ce voyage Vietnam Cambodge par le Mekong vous permet de dcouvrir un Delta du Mekong autrement, Approche solidaire respectueuse de lenvironnement. Callery CD, Rosen PR, Kinne DW: Sarcoma of the breast: a study of 32 patients with reappraisal of classification and therapy. sclerosing stromal ovary tumor sst radiopaedia venous breast literature neoplasia endocrine associated cancer multiple case report type review findings lumpectomy histologic mass right after stain fibrosis periductal PSS is a tumor of intermediate behavior; it may evolve into a phyllode tumor as well as a specific soft-tissue sarcoma. Imaging analysis: SZ, MW, MY, YJ, HL, FZ, ND, LK. Periductal Stromal Sarcoma in a Child: A Case Report. Remarkable subcutaneous varicose veins were shown in her right breast. Wabik A, Van Bockstal MR, Berlire M, Galant C. Int J Surg Pathol. Breast Imaging-Reporting and Data System (BI-RADS) 3. FOIA Fortunately, until the very last follow-up, no sign of local recurrence or distant metastasis is noted. By using this website, you agree to our The reported mass size was diversified between 0.2 and 20 cm (16, 1416). Puisez votre inspiration dans nos propositions d'excursionet petit petit, dessinez lavtre. Immunohistochemistry was used Cite this article. 10.1097/00000478-199407000-00008. government site. International journal of surgical pathology. entity sarcoma stromal breast primary rare Treatment can be either wide local excision or mastectomy to achieve histologically clear margins. info@meds.or.ke Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Stromal periductal proliferation arranged within fat tissue (hematoxylin and eosin stain; original magnification, 50). WebCriteria for periductal stromal hyperplasia included 1) nodular, bland stroma growing as cuffs around normal or altered ducts, 2) no to minimal atypia, and 3) at most 02 stromal mitotic figures per 10 high power fields. For this case, a 3-month interval follow-up plan was recommended. Compared with FFDM alone, DBT plus FFDM demonstrated higher cancer detection rate (18). Pathol Int. The histologic characteristics to be considered are many and often heterogeneous in the same lesion which makes interpretation in needle biopsy material difficult. Epub 2020 Jun 9. The tumor measures ____ in maximal dimension and is clear from (specify if < 1 cm ____) / involves the resection margins. 2018 Nov;48(6):770-775. European journal of radiology. Ils expriment lesprit qui anime nos quipes franco - Vietnamiennes : partager des coups de cur et surtout des moments privilgis, riches en contacts humains. Finding stromal fronds on histology allows the correct diagnosis. NM, IB, and MA made contributions to the conception and design of the report and to the acquisition of data. 10.1097/00000658-198504000-00020. Masbah O, Lalya I, Mellas N, et al. Disclaimer. Burga AM, Tavassoli FA. doi:10.3892/ol.2014.2294, 4. The size may range from 1 to 45 cm and may occupy the entire breast. [16][17], PAX3 and SIX1 expression by immunohistochemistry and gene expression analysis have recently been identified in borderline and malignant phyllodes tumors and correlate with a poor clinical outcome.[18]. 2023 BioMed Central Ltd unless otherwise stated. Which of the following features can be seen in malignant phyllodes tumors but not metaplastic carcinomas? Ce circuit Nord Est du Vietnam la dcouverte des endroits insolites et hors du tourisme de masse. Guarantor of integrity of the entire case study: LK, ZJ, HX. The American journal of surgical pathology. [1], This variety comprises 60% to 75% of all phyllodes tumors. Google Scholar. Edited by: Tavassoli FA, Devilee P. 2003, Lyon: IARC Press, 101-102. 2005 Sep 1;91(3):185-94. doi: 10.1002/jso.20334. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Chong A, Weinstein SP, McDonald ES, Conant EF. Therefore, close follow-up is required. The studies involving human participants were reviewed and approved by the Institutional Review Board (IRB) of Peking Union Medical College Hospital (PUMCH) that has reviewed the study. On physical examination, her right breast was grossly plumper than the opposite, with an approximately 8-cm palpable mass, which was painless and mobile. Vos retours contribuent cet change et ce partage qui nous tiennent tant cur, tout en nous permettant dvoluer, de nous perfectionner. It is characterized by proliferation of atypical spindle cells surrounding benign mammary In addition to epithelial cells from the ducts and lobules, phyllodes tumors can also contain stromal cells. tumor stromal periductal spindle exhibiting breast atypical benign ducts Breast periductal stromal tumor (PDST) is a rare condition and accounts for less than 1% of all breast malignancies. The lesion was histologically compatible with low-grade PSS. stromal tumor periductal breast overgrowth The patient, with no family history of breast cancer, had a history of fibroadenoma excision of the left breast 27 years ago. The primary care provider and nurse practitioner must refer patients with suspected breast masses to an oncologist for further workup. As far as we know, no classic imaging features have been reported due to the rarity of PDST. A 48-year-old woman was admitted with an 8-year history of right breast mass. Sosin M, Pulcrano M, Feldman ED, Patel KM, Nahabedian MY, Weissler JM, et al. Other names for these tumors include phylloides tumor and cystosarcoma phyllodes. Web+254-730-160000 +254-719-086000. Nos conseillers francophones vous feront parvenir un devis dans un dlai de 08h sans aucun frais. In this case, infiltrative growth, rich in interstitial cells, obvious atypia, active mitosis (>10/10 HPF or 5/mm2), and pathological mitosis indicated malignancy. After excision of the mass, she was followed up in the outpatient clinic for 25 months without local recurrence or distant metastasis. Am J Surg Pathol (2003) 27:3438. The closest distance between the tumor and resection margins ranged from 2mm to 13mm. WebPeriductal Stromal Tumor of the Breast: One Institution's Review of 6 Tumors Over a 22 Year Period With Immunohistochemical Analysis Int J Surg Pathol. 10.1097/00000478-200303000-00007. Authors Longmei Zhao 1 , Miglena K Komforti 1 , Andrea Dawson 1 , J Jordi Rowe 1 Affiliation The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. T2-weighted images usually show a lobulated mass with hyperintense fluid in slit-like spaces and sometimes hyperintensity in the surrounding tissues. Tel : +33603369775 Presurgery imaging plays an important role in the surgical planning and the follow-up management of PDST. Some regard tumors with predominant periductal stromal expansion (i.e., periductal stromal tumor) as a distinct subtype of phyllodes tumor Graded into benign, borderline and malignant histologic grades *Defined as absence of epithelial elements containing stroma only in 1 low power field 2003, 27: 343-348. Une croisire le long de la rivire et une baladesur les marchs flottants sur le Mekong. 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